ELISA AATF anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease(presenile and senile dementia), althoµgh the molecµLar basis for this phenomenon has not been described to date. Immunogen:apoptosis antagonizing transcription factor Synonyms:AATF, CHE 1, CHE1, DED, Protein AATF, Rb binding protein Che 1, Traube Observed MW:63 kDa Uniprot ID:Q9NY61 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IF Recommended dilution:WB: 1:200-1:2000; IF: 1:10-1:100 Gene ID:26574 Research Area:Metabolism