ELISA Recombinant Transcription intermediary factor 1-alpha(TRIM24),partial

Quantity: 200µg. Other Quantitys are also available. Please Inquire. In Stock: No Lead time: 22-32 working days Research Topic: Epigenetics and Nuclear Signaling Uniprot ID: O15164 Gene Names: TRIM24 Organism: Homo sapiens () AA Sequence: KKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPK Expression Region: 891-1012aa Sequence Info: Partial Source: Yeast Tag Info: N-terminal 6xHis-tagged MW: 16.5 kDa Alternative Name(s): E3 ubiquitin-protein ligase TRIM24RING finger protein 82Tripartite motif-containing protein 24 Relevance: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modµLates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regµLation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regµLates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. ModµLates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regµLating retinoic acid-dependent proliferation of hepatocytes Reference: Differential interaction of nuclear receptors with the putative transcriptional coactivator hTIF1.Thenot S., Henriquet C., Rochefort H., Cavailles V.J. Biol. Chem. 272:12062-12068(1997) Purity: Greater than 90% as determined by SDS-PAGE. Storage Buffer: Tris-based buffer，50% glycerol Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.