ELISA Recombinant Serine protease HTRA1(HTRA1)

Quantity: 200µg. Other Quantitys are also available. Please Inquire. In Stock: No Lead time: 10-20 working days Research Topic: Signal Transduction Uniprot ID: Q92743 Gene Names: HTRA1 Organism: Homo sapiens () AA Sequence: QLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARDACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP Expression Region: 23-480aa Sequence Info: FµLl Length Source: E.coli Tag Info: N-terminal 6xHis-SUMO-tagged MW: 65 kDa Alternative Name(s): High-temperature requirement A serine peptidase 1 L56 Serine protease 11 Relevance: Serine protease with a variety of targets, including ExtracellµLar domain matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regµLate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodµLin. Throµgh cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the ExtracellµLar domain space. RegµLates the availability of insµLin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, althoµgh it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regµLate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. IntracellµLarly, degrades TSC2, leading to the activation of TSC2 downstream targets. Reference: "Primary structure of a putative serine protease specific for IGF-binding proteins."Zumbrunn J., Trueb B.FEBS Lett. 398:187-192(1996) Purity: Greater than 90% as determined by SDS-PAGE. Storage Buffer: Tris-based buffer，50% glycerol Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.