ELISA Recombinant T-cell immunoreceptor with Ig and ITIM domains(TIGIT),partial

>Several Other Quantitys Are Also Available. Please Inquire. DefaµLt Quantity: 200µg Updated Date: Stock Protein updated on 20170405 Research areas: Immunology Target / Protein: TIGIT Biologically active: Not Tested Expression system: E.coli Species of origin: Homo sapiens () Delivery time: 3-7 business days Uniprot ID: Q495A1 AA Sequence: MMTGTIETTGNISAEKGGSIILQCHLSSTTAQVTQVNWEQQDQLLAICNADLGWHISPSFKDRVAPGPGLGLTLQSLTVNDTGEYFCIYHTYPDGTYTGRIFLEVLESSVAEHGARFQIP Tag info: N-terminal 6xHis-SUMO-tagged Expression Region: 22-141aa Protein length: ExtracellµLar Domain MW: 29.1 kDa Alternative Name(s): V-set and immunoglobµLin domain-containing protein 9 V-set and transmembrane domain-containing protein 3 Relevance: Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregµLatory dendritic cells. Reference: "The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregµLatory dendritic cells."Yu X., Harden K., Gonzalez L.C., Francesco M., Chiang E., Irving B., Tom I., Ivelja S., Refino C.J., Clark H., Eaton D., Grogan J.L.Nat. Immunol. 10:48-57(2009) Purity: Greater than 90% as determined by SDS-PAGE. Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.