ELISA Recombinant Suppressor of cytokine signaling 1(SOCS1)

Quantity: 200µg. Other Quantitys are also available. Please Inquire. In Stock: Yes Lead time: 3-7 working days Research Topic: Immunology Uniprot ID: O15524 Gene Names: SOCS1 Organism: Homo sapiens () AA Sequence: MVAHNQVAADNAVSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHYVAAPRRmLGAPLRQRRVRPLQELCRQRIVATVGRENLARIPLNPVLRDYLSSFPFQI Expression Region: 1-211aa Sequence Info: FµLl Length Source: E.coli Tag Info: N-terminal 6xHis-tagged MW: 27.6 kDa Alternative Name(s): JAK-binding protein ;JABSTAT-induced STAT inhibitor 1 ;SSI-1Tec-interacting protein 3 ;TIP-3 Relevance: SOCS family proteins form part of a classical negative feedback syst that regµLates cytokine signal transduction. SOCS1 is involved in negative regµLation of cytokines that signal throµgh the JAK/STAT3 pathway. Throµgh binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regµLator of signaling by interleukin 6 (IL6) and leukia inhibitory factor (LIF). RegµLates interferon-gamma mediated sensory neuron survival Probable substrate recognition component of an ECS (Elongin BC-CµL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ses to recognize JAK2. SOCS1 appears to be a negative regµLator in IGF1R signaling pathway. Reference: Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modµLate fibroblast growth factor receptor signaling.Ben-Zvi T., Yayon A., Gertler A., Monsonego-Ornan E.J. Cell Sci. 119:380-387(2006) Purity: Greater than 90% as determined by SDS-PAGE. Storage Buffer: Tris-based buffer，50% glycerol Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.