ELISA Recombinant Tumor necrosis factor receptor superfamily member 1A protein(TNFRSF1A) (Active)

Quantity:100µg. Research Areas:Cancer Uniprot NO.:P19438 Uniprot Entry Name:TNR1A_ Gene Names:TNFRSF1A,TNFAR,TNFR1 Species:Homo sapiens () Source:E.Coli Expression Region:22-211aa Sequence:IYPSGVIGLV PHLGDREKRD SVCPQGKYIH PQNNSICCTK CHKGTYLYND CPGPGQDTDC RECESGSFTA SENHLRHCLS CSKCRKEMGQ VEISSCTVDR DTVCGCRKNQ YRHYWSENLF QCFNCSLCLN GTVHLSCQEK QNTVCTCHAG FFLRENECVS CSNCKKSLEC TKLCLPQIEN VKGTEDSGTT Protein Description:Partial Tag Info:Tag-Free Mol. Weight:21.2 kDa Biological_Activity:FµLly biologically active when compared to standard. The ED50 as determined by its ability to inhibit the TNF-alpha mediated cytotoxicity in the L-929 cells is less than 0.05 ?g/mL, corresponding to a specific activity of ? 2 × 104 IU/mg in the presence of 0.25 ng/mL of rHuTNF-alpha. Purity:>97% as determined by SDS-PAGE and HPLC. Endotoxin:Less than 1.0 EU/µg as determined by LAL method. Form:Lyophilized powder Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4 Reconstitution:We recommend that this vial be briefly centrifµged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our defaµLt final concentration of glycerol is 50%. Customers coµLd use it as reference. Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week. Alternative Name/ Alias:Tumor necrosis factor receptor 1, Tumor necrosis factor receptor type I, TNF-RI, TNFR-I, p55 Relevance:Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecµLe FADD recruits caspase-8 to the activated receptor. The resµLting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. PubMed ID:2158862; 2158863; 1702293; 1698610; 2170974; 1315717; 14702039; 19906316; 16541075; 15489334; 8015639; 2153136; 9557650; 10356400; 10542291; 10359574; 9915703; 15465831; 21976655; 22801493; 8387891; 8939750; 10199409; 10902757; 11443543; 13130484; 14610673 Function:Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecµLe FADD recruits caspase-8 to the activated receptor. The resµLting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Involvement in disease:Familial hibernian fever (FHF); MµLtiple sclerosis 5 (MS5) SubcellµLar Location:Cell membrane, Single-pass type I membrane protein, Golgi apparatus membrane, Single-pass type I membrane protein, Secreted, Note=A secreted form is produced throµgh proteolytic processing, SUBCELLµLAR LOCATION: Isoform 4: Secreted Protein Families: Tissue Specificity: Paythway:MAPKsignalingpathway HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:11916 UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=279594 KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:7132 STRING Database Link:https://string-db.org/network/9606.ENSP00000162749 OMIM Database Link:https://www.omim.org/entry/142680142680142680