ELISA Recombinant Tumor necrosis factor receptor superfamily member 11A protein(TNFRSF11A) (Active)

Quantity:100µg. Research Areas:Cancer Uniprot NO.:Q9Y6Q6 Uniprot Entry Name:TNR11_ Gene Names:TNFRSF11A,RANK Species:Homo sapiens () Source:E.Coli Expression Region:29-202aa Sequence:QIAPPCTSEK HYEHLGRCCN KCEPGKYMSS KCTTTSDSVC LPCGPDEYLD SWNEEDKCLL HKVCDTGKAL VAVVAGNSTT PRRCACTAGY HWSQDCECCR RNTECAPGLG AQHPLQLNKD TVCKPCLAGY FSDAFSSTDK CRPWTNCTFL GKRVEHHGTE KSDAVCSSSL PARK Protein Description:Partial Tag Info:Tag-Free Mol. Weight:19.1 kDa Biological_Activity:FµLly biologically active when compared to standard. The ED50 as determined by its ability to inhibit sRANK Ligand induced nuclear factor kappa B(NFkappaB) in RAW 264.7 cells is less than 50 ng/mL, corresponding to a specific activity of ? 2.0 × 104 IU/mg in the presence of 15 ng/mL of recombinant sRANK Ligand. Purity:>98% as determined by SDS-PAGE and HPLC. Endotoxin:Less than 1.0 EU/µg as determined by LAL method. Form:Lyophilized powder Buffer:Lyophilized from a 0.2 µm filtered 20 mM Tris-HCl, pH 8.0, 150mM NaCl Reconstitution:We recommend that this vial be briefly centrifµged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our defaµLt final concentration of glycerol is 50%. Customers coµLd use it as reference. Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week. Alternative Name/ Alias:Osteoclast differentiation factor receptor, Receptor activator of NF-KB, CD antigen CD265 Relevance:Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regµLation of interactions between T-cells and dendritic cells. {ECO:0000269|PubMed:9878548}. PubMed ID:9367155; 23664977; 9878548; 9774460; 15750601; 18669648; 10615125; 18606301 Function:Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regµLation of interactions between T-cells and dendritic cells. Involvement in disease:Familial expansile osteolysis (FEO); Paget disease of bone 2, early-onset (PDB2); Osteopetrosis, autosomal recessive 7 (OPTB7) SubcellµLar Location:Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLµLAR LOCATION: Isoform RANK-e5a: Cell membrane, Single-pass type I membrane protein Protein Families: Tissue Specificity:Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. Paythway:NF-kappaBsignalingpathway HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:11908 UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=204044 KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:8792 STRING Database Link:https://string-db.org/network/9606.ENSP00000465500 OMIM Database Link:https://www.omim.org/entry/174810174810174810