ELISA Recombinant Tumor necrosis factor receptor superfamily member 13C protein(TNFRSF13C) (Active)

Quantity:100µg. Research Areas:Cancer Uniprot NO.:Q96RJ3 Uniprot Entry Name:TR13C_ Gene Names:TNFRSF13C,BAFFR,BR3 Species:Homo sapiens () Source:E.Coli Expression Region:1-76aa Sequence:MRRGPRSLRG RDAPAPTPCV PAECFDLLVR HCVACGLLRT PRPKPAGASS PAPRTALQPQ ESVGAGAGEA ALPLPG Protein Description:Partial Tag Info:Tag-Free Mol. Weight:7.8 kDa Biological_Activity:FµLly biologically active when compared to standard. The ED50 as determined by its ability to block BAFF induced mouse splenocyte survival is 1.0-5.0 µg/mL in the presence of 1.0 ?g/mL of rHuBAFF. Purity:>95% as determined by SDS-PAGE. Endotoxin:Less than 1.0 EU/µg as determined by LAL method. Form:Lyophilized powder Buffer:Lyophilized from a 0.2 µm filtered 20 mM PB, pH 8.0, 500 mM NaCl Reconstitution:We recommend that this vial be briefly centrifµged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our defaµLt final concentration of glycerol is 50%. Customers coµLd use it as reference. Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week. Alternative Name/ Alias:B-cell-activating factor receptor, BAFF-R, BLyS receptor 3, CD antigen CD268, Relevance:B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. {ECO:0000269|PubMed:11591325, ECO:0000269|PubMed:12387744}. PubMed ID:11509692; 10591208; 11591325; 12387744; 12755599; 12721620; 12715002; 16840730; 16160919; 19666484 Function:B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. Involvement in disease:Immunodeficiency, common variable, 4 (CVID4) SubcellµLar Location:Membrane, Single-pass type III membrane protein Protein Families: Tissue Specificity:Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes. Paythway:NF-kappaBsignalingpathway HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:17755 UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=344088 KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:115650 STRING Database Link:https://string-db.org/network/9606.ENSP00000291232 OMIM Database Link:https://www.omim.org/entry/606269606269606269